The Volatility Basis Set (VBS) has become one of the main tools used in atmospheric science for interpreting and modeling the partitioning of gases associated with organic aerosols. In this article the authors extend the VBS to nucleation, showing that it is possible to predict particle formation rates over the full range of tropospheric temperatures, with good agreement with extensive chamber measurements. The tool provides a means to understand the chemical and physical factors affecting nucleation across a wide range of environments over the industrial period and into the future.