Articles | Volume 20, issue 9
https://doi.org/10.5194/acp-20-5197-2020
https://doi.org/10.5194/acp-20-5197-2020
Research article
 | 
04 May 2020
Research article |  | 04 May 2020

Characterization and comparison of PM2.5 oxidative potential assessed by two acellular assays

Dong Gao, Krystal J. Godri Pollitt, James A. Mulholland, Armistead G. Russell, and Rodney J. Weber

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Cited articles

Abrams, J. Y., Weber, R. J., Klein, M., Sarnat, S. E., Chang, H. H., Strickland, M. J., Verma, V., Fang, T., Bates, J. T., Mulholland, J. A., Russell, A. G., and Tolbert, P. E.: Associations between Ambient Fine Particulate Oxidative Potential and Cardiorespiratory Emergency Department Visits, Environ. Health Persp., 125, 107008, https://doi.org/10.1289/EHP1545, 2017. 
Aliaga, M. E., Carrasco-Pozo, C., Lopez-Alarcon, C., and Speisky, H.: The Cu(I)-glutathione complex: factors affecting its formation and capacity to generate reactive oxygen species, Transit. Metal Chem., 35, 321–329, 2010. 
Atkinson, R. W., Samoli, E., Analitis, A., Fuller, G. W., Green, D. C., Anderson, H. R., Purdie, E., Durister, C., Aitlhadj, L., Kelly, F. J., and Mudway, I. S.: Short-term associations between particle oxidative potential and daily mortality and hospital admissions in London, Int. J. Hyg. Envir. Heal. 219, 566–572, 2016. 
Ayres, J. G., Borm, P., Cassee, F. R., Castranova, V., Donaldson, K., Ghio, A., Harrison, R. M., Hider, R., Kelly, F., Kooter, I. M., Marano, F., Maynard, R. L., Mudway, I., Nel, A., Sioutas, C., Smith, S., Baeza-Squiban, A., Cho, A., Duggan, S., and Froines, J.: Evaluating the toxicity of airborne particulate matter and nanoparticles by measuring oxidative stress potential – A workshop report and consensus statement, Inhal. Toxicol., 20, 75–99, 2008. 
Baker, M. A., Cerniglia, G. J., and Zaman, A.: Microtiter Plate Assay for the Measurement of Glutathione and Glutathione Disulfide in Large Numbers of Biological Samples, Anal. Biochem., 190, 360–365, 1990. 
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Short summary
This study provides a direct intercomparison between two assays for quantifying oxidative potential (OP) of ambient particles: the synthetic respiratory-tract-lining fluid (RTLF) assay and the dithiothreitol (DTT) assay. The results suggest that the DTT assay and the ascorbic acid depletion in RTLF are associated with organic species, transition metal ions, and antagonistic interactions between species. The glutathione depletion in RTLF is strongly dependent on water-soluble copper.
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