Articles | Volume 20, issue 9
Research article
04 May 2020
Research article |  | 04 May 2020

Characterization and comparison of PM2.5 oxidative potential assessed by two acellular assays

Dong Gao, Krystal J. Godri Pollitt, James A. Mulholland, Armistead G. Russell, and Rodney J. Weber


Interactive discussion

Status: closed
Status: closed
AC: Author comment | RC: Referee comment | SC: Short comment | EC: Editor comment
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Peer-review completion

AR: Author's response | RR: Referee report | ED: Editor decision
AR by Dong Gao on behalf of the Authors (16 Feb 2020)  Author's response    Manuscript
ED: Referee Nomination & Report Request started (17 Feb 2020) by Alex Lee
RR by Anonymous Referee #1 (15 Mar 2020)
ED: Publish subject to minor revisions (review by editor) (23 Mar 2020) by Alex Lee
AR by Dong Gao on behalf of the Authors (23 Mar 2020)  Author's response    Manuscript
ED: Publish as is (26 Mar 2020) by Alex Lee
Short summary
This study provides a direct intercomparison between two assays for quantifying oxidative potential (OP) of ambient particles: the synthetic respiratory-tract-lining fluid (RTLF) assay and the dithiothreitol (DTT) assay. The results suggest that the DTT assay and the ascorbic acid depletion in RTLF are associated with organic species, transition metal ions, and antagonistic interactions between species. The glutathione depletion in RTLF is strongly dependent on water-soluble copper.
Final-revised paper