Articles | Volume 20, issue 9
https://doi.org/10.5194/acp-20-5197-2020
https://doi.org/10.5194/acp-20-5197-2020
Research article
 | 
04 May 2020
Research article |  | 04 May 2020

Characterization and comparison of PM2.5 oxidative potential assessed by two acellular assays

Dong Gao, Krystal J. Godri Pollitt, James A. Mulholland, Armistead G. Russell, and Rodney J. Weber

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AC: Author comment | RC: Referee comment | SC: Short comment | EC: Editor comment
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AR: Author's response | RR: Referee report | ED: Editor decision
AR by Dong Gao on behalf of the Authors (16 Feb 2020)  Author's response   Manuscript 
ED: Referee Nomination & Report Request started (17 Feb 2020) by Alex Lee
RR by Anonymous Referee #1 (15 Mar 2020)
ED: Publish subject to minor revisions (review by editor) (23 Mar 2020) by Alex Lee
AR by Dong Gao on behalf of the Authors (23 Mar 2020)  Author's response   Manuscript 
ED: Publish as is (26 Mar 2020) by Alex Lee
AR by Dong Gao on behalf of the Authors (26 Mar 2020)
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Short summary
This study provides a direct intercomparison between two assays for quantifying oxidative potential (OP) of ambient particles: the synthetic respiratory-tract-lining fluid (RTLF) assay and the dithiothreitol (DTT) assay. The results suggest that the DTT assay and the ascorbic acid depletion in RTLF are associated with organic species, transition metal ions, and antagonistic interactions between species. The glutathione depletion in RTLF is strongly dependent on water-soluble copper.
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