Articles | Volume 17, issue 18
https://doi.org/10.5194/acp-17-11423-2017
https://doi.org/10.5194/acp-17-11423-2017
Research article
 | 
26 Sep 2017
Research article |  | 26 Sep 2017

Inflammatory responses to secondary organic aerosols (SOA) generated from biogenic and anthropogenic precursors

Wing Y. Tuet, Yunle Chen, Shierly Fok, Julie A. Champion, and Nga L. Ng

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Subject: Aerosols | Research Activity: Laboratory Studies | Altitude Range: Troposphere | Science Focus: Chemistry (chemical composition and reactions)
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Cited articles

Akhtar, U. S., McWhinney, R. D., Rastogi, N., Abbatt, J. P., Evans, G. J., and Scott, J. A.: Cytotoxic and proinflammatory effects of ambient and source-related particulate matter (PM) in relation to the production of reactive oxygen species (ROS) and cytokine adsorption by particles, Inhal. Toxicol., 22, 37–47, 2010.
Anderson, J. O., Thundiyil, J. G., and Stolbach, A.: Clearing the Air: A Review of the Effects of Particulate Matter Air Pollution on Human Health, J. Med. Toxicol., 8, 166–175, https://doi.org/10.1007/s13181-011-0203-1, 2011.
Arashiro, M., Lin, Y.-H., Sexton, K. G., Zhang, Z., Jaspers, I., Fry, R. C., Vizuete, W. G., Gold, A., and Surratt, J. D.: In vitro exposure to isoprene-derived secondary organic aerosol by direct deposition and its effects on COX-2 and IL-8 gene expression, Atmos. Chem. Phys., 16, 14079–14090, https://doi.org/10.5194/acp-16-14079-2016, 2016.
Baird, W. M., Hooven, L. A., and Mahadevan, B.: Carcinogenic polycyclic aromatic hydrocarbon-DNA adducts and mechanism of action, Environ. Mol. Mutagen., 45, 106–114, https://doi.org/10.1002/em.20095, 2005.
Baltensperger, U., Dommen, J., Alfarra, R., Duplissy, J., Gaeggeler, K., Metzger, A., Facchini, M. C., Decesari, S., Finessi, E., Reinnig, C., Schott, M., Warnke, J., Hoffmann, T., Klatzer, B., Puxbaum, H., Geiser, M., Savi, M., Lang, D., Kalberer, M., and Geiser, T.: Combined determination of the chemical composition and of health effects of secondary organic aerosols: The POLYSOA project, J. Aerosol Med. Pulm. Drug Deliv., 21, 145–154, https://doi.org/10.1089/jamp.2007.0655, 2008.
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Short summary
Exposure to secondary organic aerosols (SOAs) may have cardiopulmonary health implications. Alveolar macrophages were exposed to various SOA systems and reactive oxygen and nitrogen species production and cytokine secretion was measured post-exposure. Results from this study show that the chemical structure of SOA products may be important for determining cellular responses and demonstrate that the health effects of SOA are important to consider for the health implications of ambient aerosols.
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