H₂SO₄–organics clustering thermodynamics from quantum studies has been employed to develop a scheme to include temperature dependence in an H₂SO₄–organics nucleation parameterization. We show that temperature has a strong impact on nucleation rates, particle number concentrations, and aerosol first indirect radiative forcing in summer. To our knowledge, the study represents the first attempt to study the temperature effect on organics-mediated nucleation in the global atmosphere.