Methane is a potent greenhouse gas with a global warming potential much greater than carbon dioxide. In order to understand and limit its global warming effect, it is important to have have observation systems to estimate its anthropogenic emissions. This paper analyses in a novel way TROPOMI satellite observations to track methane emissions from the largest oil production basin in the United States over a 2-year period. The analysis shows that emission variability and trends are driven by multiple factors, among which new well development and natural gas spot price are the most significant ones. The work is an excellent demonstration of the potential of satellite observations for near-real-time monitoring of methane emissions. It opens a broad range of applications, helping science and policy to understand and mitigate climate change.