Authors,

Thank you for your submission to ACP. I am pleased with your revisions in response to the three sets of referee comments. I have a few minor technical points to consider revising (see below), but otherwise I am happy for the manuscript to proceed to publication.

Congratulations and best regards,

Alex Huffman

Technical points of correction:
- Your response to comment #3 from referee #2 is informative. I suggest adding a version of this, including the figure, to the online supplement.
- I have found working on similar chromatographic techniques that comparing a few raw chromatograms can be useful to support confidence in the work and to help citing authors to compare their work with yours. I will not hold you to this suggestion, but you may consider adding a few raw chromatograms to the supplement, showing e.g. a calibration run and one or two sample runs.
- In response to the last big comment from referee #3 you mentioned a publication in Sci. Advances. Unless I missed it, I don't think you referenced this paper, but I think it could be useful to add explanation with respect to the referee's comment. Please add the citation as "In Review" or whatever the most appropriate current citation should be.
- A number of the figures are fuzzy, i.e. reproduced at relatively low resolution. This is fine for now, but please make sure to increase resolution for final figure upload.
- The caption of Figure 5 should be updated to include specific reference to the dashed line. The caption mentions the reason, but I suggest adding e.g. "(dashed line)" to make it explicitly clear.
- The font size is relatively small in a number of figures, and I suggest increasing. E.g. Figures 6, 7.