Articles | Volume 18, issue 3
Research article
16 Feb 2018
Research article |  | 16 Feb 2018

Evaluating the mutagenic potential of aerosol organic compounds using informatics-based screening

Stefano Decesari, Simona Kovarich, Manuela Pavan, Arianna Bassan, Andrea Ciacci, and David Topping


Interactive discussion

Status: closed
Status: closed
AC: Author comment | RC: Referee comment | SC: Short comment | EC: Editor comment
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Peer-review completion

AR: Author's response | RR: Referee report | ED: Editor decision
AR by Stefano Decesari on behalf of the Authors (27 Oct 2017)  Author's response   Manuscript 
ED: Referee Nomination & Report Request started (17 Nov 2017) by Athanasios Nenes
RR by Anonymous Referee #1 (24 Nov 2017)
RR by Anonymous Referee #2 (27 Nov 2017)
ED: Publish as is (29 Dec 2017) by Athanasios Nenes
AR by Stefano Decesari on behalf of the Authors (08 Jan 2018)
Short summary
Particulate matter (PM) chemical composition includes thousands of individual organic compounds that have never been tested for their toxicological potential. Computational (in silico) screenings represent a promising approach to identify new target compounds for more in-depth toxicological analyses. We provide here a proof-of-concept evaluation based on ca. 100 aerosol organic compounds. Reliable toxicological predictions were obtained for more than 80 % of them.
Final-revised paper