Light-induced protein nitration and degradation with HONO emission

Meusel, Hannah; Elshorbany, Yasin; Kuhn, Uwe; Bartels-Rausch, Thorsten; Reinmuth-Selzle, Kathrin; Kampf, Christopher J.; Li, Guo; Wang, Xiaoxiang; Lelieveld, Jos; Pöschl, Ulrich; Hoffmann, Thorsten; Su, Hang; Ammann, Markus; Cheng, Yafang

doi:https://doi.org/10.5194/acp-17-11819-2017

Articles | Volume 17, issue 19

https://doi.org/10.5194/acp-17-11819-2017

© Author(s) 2017. This work is distributed under
the Creative Commons Attribution 3.0 License.

https://doi.org/10.5194/acp-17-11819-2017

© Author(s) 2017. This work is distributed under
the Creative Commons Attribution 3.0 License.

Articles | Volume 17, issue 19

Research article

|

06 Oct 2017

Research article |

| 06 Oct 2017

Light-induced protein nitration and degradation with HONO emission

Hannah Meusel, Yasin Elshorbany, Uwe Kuhn, Thorsten Bartels-Rausch, Kathrin Reinmuth-Selzle, Christopher J. Kampf, Guo Li, Xiaoxiang Wang, Jos Lelieveld, Ulrich Pöschl, Thorsten Hoffmann, Hang Su, Markus Ammann, and Yafang Cheng

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Final revised paper (published on 06 Oct 2017)
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Preprint (discussion started on 28 Mar 2017)

Interactive discussion

Status: closed

AC: Author comment | RC: Referee comment | SC: Short comment | EC: Editor comment

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RC1: 'Reviewer comments for acp-2017-277', Anonymous Referee #1, 30 Apr 2017
- AC1: 'response to referee 1', Hannah Meusel, 09 Aug 2017
RC2: 'Review of Meusel et al. [2017]', Anonymous Referee #2, 01 May 2017
- AC3: 'response to referee 2', Hannah Meusel, 09 Aug 2017
RC3: 'Review of Meusel et al.', Anonymous Referee #3, 08 May 2017
- AC2: 'response to referee 3', Hannah Meusel, 09 Aug 2017

Peer-review completion

AR: Author's response | RR: Referee report | ED: Editor decision

AR by Hannah Meusel on behalf of the Authors (09 Aug 2017) Author's response Manuscript

ED: Referee Nomination & Report Request started (18 Aug 2017) by Alexander Laskin

RR by Anonymous Referee #2 (03 Sep 2017)

ED: Publish as is (03 Sep 2017) by Alexander Laskin

AR by Hannah Meusel on behalf of the Authors (04 Sep 2017)

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Short summary

In this study we investigated protein nitration and decomposition by light in the presence of NO₂ via flow tube measurements. Nitrated proteins have an enhanced allergenic potential but so far nitration was only studied in dark conditions. Under irradiated conditions we found that proteins predominantly decompose while forming nitrous acid (HONO) an important precursor of the OH radical. Unlike other studies on heterogeneous NO₂ conversion we found a stable HONO formation over a long period.