Articles | Volume 16, issue 22
https://doi.org/10.5194/acp-16-14079-2016
© Author(s) 2016. This work is distributed under
the Creative Commons Attribution 3.0 License.
the Creative Commons Attribution 3.0 License.
https://doi.org/10.5194/acp-16-14079-2016
© Author(s) 2016. This work is distributed under
the Creative Commons Attribution 3.0 License.
the Creative Commons Attribution 3.0 License.
Research article
| 
15 Nov 2016
Research article |
| 15 Nov 2016
In vitro exposure to isoprene-derived secondary organic aerosol by direct deposition and its effects on COX-2 and IL-8 gene expression
Maiko Arashiro
Department of Environmental Sciences and Engineering, Gillings School
of Global Public Health, University of North Carolina at Chapel Hill, Chapel
Hill, NC 27599, USA
Ying-Hsuan Lin
Department of Environmental Sciences and Engineering, Gillings School
of Global Public Health, University of North Carolina at Chapel Hill, Chapel
Hill, NC 27599, USA
Michigan Society of Fellows, Department of Chemistry, University of
Michigan, Ann Arbor, MI 48109, USA
Kenneth G. Sexton
Department of Environmental Sciences and Engineering, Gillings School
of Global Public Health, University of North Carolina at Chapel Hill, Chapel
Hill, NC 27599, USA
Zhenfa Zhang
Department of Environmental Sciences and Engineering, Gillings School
of Global Public Health, University of North Carolina at Chapel Hill, Chapel
Hill, NC 27599, USA
Ilona Jaspers
Department of Environmental Sciences and Engineering, Gillings School
of Global Public Health, University of North Carolina at Chapel Hill, Chapel
Hill, NC 27599, USA
Center for Environmental Medicine, Asthma, and Lung Biology, School
of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC
27599, USA
Curriculum in Toxicology, University of North Carolina at Chapel
Hill, Chapel Hill, NC 27599, USA
Department of Pediatrics, School of Medicine, University of North
Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Department of Microbiology and Immunology, School of Medicine,
University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Rebecca C. Fry
Department of Environmental Sciences and Engineering, Gillings School
of Global Public Health, University of North Carolina at Chapel Hill, Chapel
Hill, NC 27599, USA
Curriculum in Toxicology, University of North Carolina at Chapel
Hill, Chapel Hill, NC 27599, USA
William G. Vizuete
Department of Environmental Sciences and Engineering, Gillings School
of Global Public Health, University of North Carolina at Chapel Hill, Chapel
Hill, NC 27599, USA
Avram Gold
Department of Environmental Sciences and Engineering, Gillings School
of Global Public Health, University of North Carolina at Chapel Hill, Chapel
Hill, NC 27599, USA
Department of Environmental Sciences and Engineering, Gillings School
of Global Public Health, University of North Carolina at Chapel Hill, Chapel
Hill, NC 27599, USA
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29 citations as recorded by crossref.
- Rationally Optimized Fluorescent Probe for Imaging Mitochondrial SO2 in HeLa Cells and Zebrafish G. Chen et al. 10.1021/acs.analchem.8b01505
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- GAPDH inhibition mediated by thiol oxidation in human airway epithelial cells exposed to an environmental peroxide S. Masood et al. 10.1016/j.redox.2024.103199
- Effect of secondary organic aerosol from isoprene-derived hydroxyhydroperoxides on the expression of oxidative stress response genes in human bronchial epithelial cells M. Arashiro et al. 10.1039/C7EM00439G
- Isoprene-Derived Secondary Organic Aerosol Induces the Expression of MicroRNAs Associated with Inflammatory/Oxidative Stress Response in Lung Cells L. Eaves et al. 10.1021/acs.chemrestox.9b00322
- Chemical oxidative potential of secondary organic aerosol (SOA) generated from the photooxidation of biogenic and anthropogenic volatile organic compounds W. Tuet et al. 10.5194/acp-17-839-2017
- Gene Expression Profiling in Human Lung Cells Exposed to Isoprene-Derived Secondary Organic Aerosol Y. Lin et al. 10.1021/acs.est.7b01967
- Exposure to naphthalene and β-pinene-derived secondary organic aerosol induced divergent changes in transcript levels of BEAS-2B cells M. Pardo et al. 10.1016/j.envint.2022.107366
- Environmentally Persistent Free Radicals: Insights on a New Class of Pollutants E. Vejerano et al. 10.1021/acs.est.7b04439
- Inflammatory responses to secondary organic aerosols (SOA) generated from biogenic and anthropogenic precursors W. Tuet et al. 10.5194/acp-17-11423-2017
- Predominance of secondary organic aerosol to particle-bound reactive oxygen species activity in fine ambient aerosol J. Zhou et al. 10.5194/acp-19-14703-2019
- Exposure of Lung Epithelial Cells to Photochemically Aged Secondary Organic Aerosol Shows Increased Toxic Effects P. Chowdhury et al. 10.1021/acs.estlett.8b00256
- Lung cell exposure to secondary photochemical aerosols generated from OH oxidation of cyclic siloxanes B. King et al. 10.1016/j.chemosphere.2019.125126
- Cytotoxicity and oxidative stress induced by atmospheric mono-nitrophenols in human lung cells F. Khan et al. 10.1016/j.envpol.2022.119010
- Live cell imaging of oxidative stress in human airway epithelial cells exposed to isoprene hydroxyhydroperoxide S. Masood et al. 10.1016/j.redox.2022.102281
- Weight loss and abnormal lung inflammation in mice chronically exposed to secondary organic aerosols T. Déméautis et al. 10.1039/D2EM00423B
- Effects of NO and SO2 on the secondary organic aerosol formation from isoprene photooxidation Z. Zhang et al. 10.1016/j.atmosenv.2023.120248
- Toxicological Responses of α-Pinene-Derived Secondary Organic Aerosol and Its Molecular Tracers in Human Lung Cell Lines F. Khan et al. 10.1021/acs.chemrestox.0c00409
- Pathogenic Mechanisms of Secondary Organic Aerosols T. Déméautis et al. 10.1021/acs.chemrestox.1c00353
- Short-lived reactive components substantially contribute to particulate matter oxidative potential S. Campbell et al. 10.1126/sciadv.adp8100
- Chronic Exposure to Secondary Organic Aerosols Causes Lung Tissue Damage T. Déméautis et al. 10.1021/acs.est.2c08753
- Photochemical Conversion of Surrogate Emissions for Use in Toxicological Studies: Role of Particulate- and Gas-Phase Products J. Krug et al. 10.1021/acs.est.7b04879
- Aging Effects on the Toxicity Alteration of Different Types of Organic Aerosols: A Review R. Lei et al. 10.1007/s40726-023-00272-9
- Heterogeneous Oxidation Products of Fine Particulate Isoprene Epoxydiol-Derived Methyltetrol Sulfates Increase Oxidative Stress and Inflammatory Gene Responses in Human Lung Cells F. Khan et al. 10.1021/acs.chemrestox.3c00278
- Additional Benefits of Federal Air-Quality Rules: Model Estimates of Controllable Biogenic Secondary Organic Aerosol A. Carlton et al. 10.1021/acs.est.8b01869
- The acidity of atmospheric particles and clouds H. Pye et al. 10.5194/acp-20-4809-2020
- Characterization of chemical and bioreactivity properties of photooxidation reaction products from secondary organic aerosols (SOA) under high OH exposure condition K. Lui et al. 10.1016/j.atmosenv.2025.121212
- Development of a Novel Simulation Reactor for Chronic Exposure to Atmospheric Particulate Matter J. Ye et al. 10.1038/srep42317
- Chemical and cellular oxidant production induced by naphthalene secondary organic aerosol (SOA): effect of redox-active metals and photochemical aging W. Tuet et al. 10.1038/s41598-017-15071-8
27 citations as recorded by crossref.
- Rationally Optimized Fluorescent Probe for Imaging Mitochondrial SO2 in HeLa Cells and Zebrafish G. Chen et al. 10.1021/acs.analchem.8b01505
- Oxidative and Toxicological Evolution of Engineered Nanoparticles with Atmospherically Relevant Coatings Q. Liu et al. 10.1021/acs.est.8b06879
- GAPDH inhibition mediated by thiol oxidation in human airway epithelial cells exposed to an environmental peroxide S. Masood et al. 10.1016/j.redox.2024.103199
- Effect of secondary organic aerosol from isoprene-derived hydroxyhydroperoxides on the expression of oxidative stress response genes in human bronchial epithelial cells M. Arashiro et al. 10.1039/C7EM00439G
- Isoprene-Derived Secondary Organic Aerosol Induces the Expression of MicroRNAs Associated with Inflammatory/Oxidative Stress Response in Lung Cells L. Eaves et al. 10.1021/acs.chemrestox.9b00322
- Chemical oxidative potential of secondary organic aerosol (SOA) generated from the photooxidation of biogenic and anthropogenic volatile organic compounds W. Tuet et al. 10.5194/acp-17-839-2017
- Gene Expression Profiling in Human Lung Cells Exposed to Isoprene-Derived Secondary Organic Aerosol Y. Lin et al. 10.1021/acs.est.7b01967
- Exposure to naphthalene and β-pinene-derived secondary organic aerosol induced divergent changes in transcript levels of BEAS-2B cells M. Pardo et al. 10.1016/j.envint.2022.107366
- Environmentally Persistent Free Radicals: Insights on a New Class of Pollutants E. Vejerano et al. 10.1021/acs.est.7b04439
- Inflammatory responses to secondary organic aerosols (SOA) generated from biogenic and anthropogenic precursors W. Tuet et al. 10.5194/acp-17-11423-2017
- Predominance of secondary organic aerosol to particle-bound reactive oxygen species activity in fine ambient aerosol J. Zhou et al. 10.5194/acp-19-14703-2019
- Exposure of Lung Epithelial Cells to Photochemically Aged Secondary Organic Aerosol Shows Increased Toxic Effects P. Chowdhury et al. 10.1021/acs.estlett.8b00256
- Lung cell exposure to secondary photochemical aerosols generated from OH oxidation of cyclic siloxanes B. King et al. 10.1016/j.chemosphere.2019.125126
- Cytotoxicity and oxidative stress induced by atmospheric mono-nitrophenols in human lung cells F. Khan et al. 10.1016/j.envpol.2022.119010
- Live cell imaging of oxidative stress in human airway epithelial cells exposed to isoprene hydroxyhydroperoxide S. Masood et al. 10.1016/j.redox.2022.102281
- Weight loss and abnormal lung inflammation in mice chronically exposed to secondary organic aerosols T. Déméautis et al. 10.1039/D2EM00423B
- Effects of NO and SO2 on the secondary organic aerosol formation from isoprene photooxidation Z. Zhang et al. 10.1016/j.atmosenv.2023.120248
- Toxicological Responses of α-Pinene-Derived Secondary Organic Aerosol and Its Molecular Tracers in Human Lung Cell Lines F. Khan et al. 10.1021/acs.chemrestox.0c00409
- Pathogenic Mechanisms of Secondary Organic Aerosols T. Déméautis et al. 10.1021/acs.chemrestox.1c00353
- Short-lived reactive components substantially contribute to particulate matter oxidative potential S. Campbell et al. 10.1126/sciadv.adp8100
- Chronic Exposure to Secondary Organic Aerosols Causes Lung Tissue Damage T. Déméautis et al. 10.1021/acs.est.2c08753
- Photochemical Conversion of Surrogate Emissions for Use in Toxicological Studies: Role of Particulate- and Gas-Phase Products J. Krug et al. 10.1021/acs.est.7b04879
- Aging Effects on the Toxicity Alteration of Different Types of Organic Aerosols: A Review R. Lei et al. 10.1007/s40726-023-00272-9
- Heterogeneous Oxidation Products of Fine Particulate Isoprene Epoxydiol-Derived Methyltetrol Sulfates Increase Oxidative Stress and Inflammatory Gene Responses in Human Lung Cells F. Khan et al. 10.1021/acs.chemrestox.3c00278
- Additional Benefits of Federal Air-Quality Rules: Model Estimates of Controllable Biogenic Secondary Organic Aerosol A. Carlton et al. 10.1021/acs.est.8b01869
- The acidity of atmospheric particles and clouds H. Pye et al. 10.5194/acp-20-4809-2020
- Characterization of chemical and bioreactivity properties of photooxidation reaction products from secondary organic aerosols (SOA) under high OH exposure condition K. Lui et al. 10.1016/j.atmosenv.2025.121212
2 citations as recorded by crossref.
- Development of a Novel Simulation Reactor for Chronic Exposure to Atmospheric Particulate Matter J. Ye et al. 10.1038/srep42317
- Chemical and cellular oxidant production induced by naphthalene secondary organic aerosol (SOA): effect of redox-active metals and photochemical aging W. Tuet et al. 10.1038/s41598-017-15071-8
Latest update: 31 Oct 2025
Short summary
Atmospheric oxidation of isoprene in the presence of acidic sulfate aerosol yields substantial SOA. Potential adverse health effects resulting from exposure to this aerosol type are largely unknown. Measurements of gene expression of known inflammatory biomarkers interleukin 8 (IL-8) and cyclooxygenase 2 (COX-2) in exposed human lung cells at the air–liquid interface showed that a dose of 0.067 μg cm−2 of isoprene SOA leads to statistically significant increases in IL-8 and COX-2 mRNA levels.
Atmospheric oxidation of isoprene in the presence of acidic sulfate aerosol yields substantial...
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