Thank you for your clear, thorough response to the reviewers. There remain a few typos and I also recommend a few minor changes to the manuscript and supplement, along the lines of the existing reviewer comments, to avoid possible future confusion.

L80: Hopke misspelled (written as Hokpe)
L81: "large period of time" is a bit awkward, consider revising
L138: please define "combined chemical dataset" more directly for the reader
L154-159: please be consistent with are/were tense in this paragraph

I suggest adding material from your responses to two reviewer comments to the supplement, which may improve the clarity and readability of the manuscript for readers outside the immediate field.
Reviewer #2, Comment #2: Please include a short discussion of artifacts (possibly including response figures a, b) in the supplement and/or main text
Reviewer #2, Comment #5: Please include this accepted definition of standard error in supplemental text, as other readers may be similarly confused