The O₃ pollution across Africa has been exacerbating, which poses serious threats to public health. In this study, we predict future near-surface O₃ concentrations with an integrated machine learning framework. This study reveals that global warming will exacerbate the health risk associated with O₃ pollution. The elevated air temperatures act as primary driver of increased mortality ratios, while enhanced O₃ concentrations are an additional stressor and adverse side effect of warming climate.