We use the chemistry version of the Weather Research and Forecasting model coupled with spectral bin microphysics to investigate how meteorological conditions impact aerosol–cloud interactions (ACI) under different pollution regimes. Our findings highlight the changes in aerosol effects on clouds and precipitation under varying thermodynamic conditions, as well as the sensitivity of ACI to meteorological conditions under different pollution regimes, which help to clarify the mechanisms behind the nonlinear variation of ACI with environmental conditions.