The purpose of this special issue is the compilation of modelling and observational studies in connection with five international field deployments (AEROCLO-sA, CLARIFY, LASIC, ORACLES, and NaFoLiCA) that focus on the interactions of natural and anthropogenic aerosols with radiation, clouds, and regional climate in the South Atlantic Ocean and the southern African region. These deployments, based in Namibia, Ascension Island, and São Tomé, took place between 2016 and 2018 and support a significant number of investigations extending beyond just the individual science teams. The airborne and ground-based observations, as well as the related satellite measurements and climate modelling studies, address all aspects of aerosol–cloud–climate interactions, including the link of aerosol properties to meteorological fields and dynamical processes that influence aerosol emission and transport. The projects also target the advancement of remote sensing of aerosols for complex scenes over land, sea, and clouds. The special issue comprises papers with complementary goals to the five mentioned deployments, so as to encourage the exchange of ideas from inside and outside the science teams of all projects.