The Aerosol Chemistry Model Intercomparison Project (AerChemMIP) is endorsed by the Coupled-Model Intercomparison Project 6 (CMIP6) and is designed to quantify the climate and air-quality impacts of aerosols and chemically reactive gases. Specifically, the aim of AerChemMIP is to answer four scientific questions. 1. How have anthropogenic emissions contributed to global radiative forcing and affected regional climate over the historical period? 2. How might future policies (on climate, air quality, and land use) affect the abundances of NTCFs and their climate impacts? 3. How do uncertainties in historical NTCF emissions affect radiative forcing estimates? 4. How important are climate feedbacks to natural NTCF emissions, atmospheric composition, and radiative effects? This special issue is to be devoted to papers that analyse targeted simulations with CMIP6 climate models to address these questions as well as papers that evaluate these models against observations. It also includes papers from other CMIP6-related activities (e.g. RFMIP, DAMIP), containing contributions to the understanding of climate forcing and feedbacks involving aerosols, reactive gases, and associated biogeochemical cycles.