<p>Aerosol-cloud interaction (ACI) plays an essential role in understanding precipitation occurrence and climate change but remains poorly understood. Conducting a climatology study on a regional or global scale constitutes a prospect better to understand ACI and its influence on precipitation and climate. This study analysed the characteristics of ACI over South Africa based on two instruments Moderate Resolution Imaging Spectroradiometer (MODIS) and Multiangle Imaging Spectroradiometer (MISR) onboard Terra satellite, and ground-based meteorology data from South Africa Weather Service (SAWS) between 2007–2016. The region mainly splits into the upper, central, and lower sub-regions based on the aerosol loading characteristics. Findings from the study show that depending on the atmospheric conditions, aerosol exhibits dual features of increasing and decreasing the potential formation of precipitating clouds. However, more often, fine-mode predominated aerosols suppress rain-bearing clouds. Furthermore, cloud top height (CTH) demonstrates upward increment from the lower to the upper part of the region, and the cloud fraction (CF) is in the downward direction. Both the CF and CTH display the characteristic enhancers of the precipitation intensity, mainly when the initial conditions necessary for rain-bearing occurs. Besides, cloud optical depth (COD) depends significantly on the liquid water path (LWP) and is suggestively associated with the aerosol-vapour ratio ingested into the cloud. Also notably, the temperature over the entire region generally increased steadily and continuously from 2013.</p>