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Preprints
https://doi.org/10.5194/acp-2020-208
© Author(s) 2020. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/acp-2020-208
© Author(s) 2020. This work is distributed under
the Creative Commons Attribution 4.0 License.

  23 Mar 2020

23 Mar 2020

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This preprint is currently under review for the journal ACP.

Effects of AIR pollution on cardiopuLmonary disEaSe in urban and peri-urban reSidents in Beijing: protocol for the AIRLESS study

Yiqun Han1,2, Wu Chen1, Lia Chatzidiakou3, Li Yan2, Hanbin Zhang2, Queenie Chan2,4, Ben Barratt2, Rod Jones3, Jing Liu5, Yangfeng Wu6,7, Meiping Zhao8, Junfeng Zhang9, Frank J. Kelly2, Tong Zhu1, and the AIRLESS team Yiqun Han et al.
  • 1BIC-ESAT and SKL-ESPC, College of Environmental Sciences and Engineering, Peking University, Beijing 100871, China
  • 2Environmental Research Group, MRC Centre for Environment and Health, King's College London, London, UK
  • 3Centre for Atmospheric Science, Department of Chemistry, University of Cambridge, UK
  • 4Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, Imperial College London, London, UK
  • 5Department of Epidemiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China
  • 6Peking University Clinical Research Institute, Beijing, China
  • 7The George Institute for Global Health at Peking University Health Science Center, Beijing, China
  • 8College of Chemistry, Peking University, Beijing, China
  • 9Duke Kunshan University, Nanjing, China
  • A full list of authors appears at the end of the paper.

Abstract. Beijing, as a representative megacity in China, is experiencing some of the most severe air pollution in the world, and its fast urbanization has led to a substantial urban and peri-urban disparities in both health status and air quality. Uncertainties remain regarding the possible causal links between individual air pollutants and health outcomes, with spatial comparative investigations of these links lacking, particularly in developing megacities. In light of this challenge, Effects of AIR pollution on cardiopuLmonary disEaSe in urban and peri-urban reSidents in Beijing (AIRLESS) was initiated with the aim of addressing the complex issue of multipollutant exposures on cardiopulmonary outcomes. The two panel studies deployed included urban and peri-urban elderly Beijing residents recruited from two established cohorts. The project was strengthened further through the measurement of an extensive range of ambient and indoor pollutants during two intensive monitoring campaigns undertaken simultaneously with the collection of health data from the panel participants. This paper presents the novel elements and methodology deployed in the AIRLESS project that addressed gaps in current understanding: namely (1) contrast of the exposure to air pollution in peri-urban and urban areas in a developing megacity, (2) a nested case (hypertensive) – control (healthy) study design to identify potential susceptible population, (3) the detailed assessments of personal exposure to air pollution in diverse indoor and outdoor environments using miniaturised portable platforms; (4) detailed assessment of the chemical composition of particulate matter; and (5) a rich collection of biological markers to understand the underlying mechanisms of health responses to air pollution.

Yiqun Han et al.

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Yiqun Han et al.

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Short summary
Panel study might be the most suitable design to link intensive air monitoring campaign for a wide range of pollutant species, personal exposure in different micro-environment, together with epidemiological studies of detailed biological changes in human. Panel study is intensive and delicate, but the related protocol papers of such kind are very limited. With the successfully collection of the rich dataset, we believe AIRLESS would set a good example for the design of a multidisciplinary study.
Panel study might be the most suitable design to link intensive air monitoring campaign for a...
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